Detalhe da pesquisa
1.
Use of CRISPR/Cas9-engineered INS-1 pancreatic ß cells to define the pharmacology of dual GIPR/GLP-1R agonists.
Biochem J
; 473(18): 2881-91, 2016 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27422784
2.
Isocitrate dehydrogenase (IDH) mutations promote a reversible ZEB1/microRNA (miR)-200-dependent epithelial-mesenchymal transition (EMT).
J Biol Chem
; 287(50): 42180-94, 2012 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23038259
3.
Heat inactivation of clinical COVID-19 samples on an industrial scale for low risk and efficient high-throughput qRT-PCR diagnostic testing.
Sci Rep
; 12(1): 2883, 2022 02 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-35190592
4.
Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility.
Sci Rep
; 12(1): 3114, 2022 02 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-35210470
5.
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission.
Nat Commun
; 13(1): 751, 2022 02 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35136068
6.
Single-dose BNT162b2 vaccine protects against asymptomatic SARS-CoV-2 infection.
Elife
; 102021 04 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33830018
7.
Application of High-Throughput Flow Cytometry in Early Drug Discovery: An AstraZeneca Perspective.
SLAS Discov
; 23(7): 719-731, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29787326
8.
Genetic evidence that Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism.
Genetics
; 171(4): 1643-54, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-16085697
9.
Isolation of Potent CGRP Neutralizing Antibodies Using Four Simple Assays.
J Biomol Screen
; 21(1): 24-34, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26450103
10.
Structure-based design of novel Chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity.
J Med Chem
; 48(13): 4332-45, 2005 Jun 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-15974586
11.
Genome engineering using Adeno-Associated Virus (AAV).
Methods Mol Biol
; 1239: 75-103, 2015.
Artigo
em Inglês
| MEDLINE | ID: mdl-25408402
12.
JBS special issue on therapeutic antibody discovery and development: biologics come of age.
J Biomol Screen
; 20(4): 433-6, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25805607
13.
Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
J Med Chem
; 54(12): 4034-41, 2011 Jun 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21526763
14.
Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.
J Med Chem
; 52(6): 1510-3, 2009 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-19256508
15.
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.
Cancer Res
; 68(8): 2850-60, 2008 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18413753
16.
Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.
Bioorg Med Chem Lett
; 17(14): 3880-5, 2007 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17570665
17.
Identification of a buried pocket for potent and selective inhibition of Chk1: prediction and verification.
Bioorg Med Chem
; 14(6): 1792-804, 2006 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16289938
18.
Identification of chemically diverse Chk1 inhibitors by receptor-based virtual screening.
Bioorg Med Chem
; 14(14): 4792-802, 2006 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16574416
19.
Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.
Bioorg Med Chem Lett
; 16(5): 1353-7, 2006 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-16325401
20.
Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.
Bioorg Med Chem Lett
; 15(4): 863-7, 2005 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15686876